Tools to enable structural systems biology, forked from SBRG/ssbio
This Python package provides a collection of tools for people with questions in the realm of structural systems biology. The main goals of this package are to:
- Provide an easy way to map hundreds or thousands of genes to their encoded protein sequences and structures
- Directly link protein structures to genome-scale metabolic models
- Demonstrate fully-featured Python scientific analysis environments in Jupyter notebooks
Example questions you can (start to) answer with this package:
- How can I determine the number of protein structures available for my list of genes?
- What is the best, representative structure for my protein?
- Where, in a metabolic network, do these proteins work?
- Where do popular mutations show up on a protein?
- How can I compare the structural features of entire proteomes?
- How do structural properties correlate with my experimental datasets?
- How can I improve the contents of my metabolic model with structural data?
Try it without installing
Binder notebooks are still in beta, but they mostly work! Third-party programs are also preinstalled in the Binder notebooks except I-TASSER and TMHMM due to licensing restrictions.
First install NGLview using pip, then install ssbio
pip install nglview jupyter-nbextension enable nglview --py --sys-prefix pip install ssbio
pip install ssbio --upgrade
pip uninstall ssbio
See: Software for a list of external programs to install, along with the functionality that they add. Most of these additional programs are used to predict or calculate properties of proteins, and are only required if you desire to calculate the described properties.
The manuscript for the ssbio package can be found and cited at .
|||Mih N, Brunk E, Chen K, Catoiu E, Sastry A, Kavvas E, Monk JM, Zhang Z, Palsson BO. 2018. ssbio: A Python Framework for Structural Systems Biology. Bioinformatics. https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/bty077/4850940.|
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