Sample TCRs according to VJ gene usage frequency
Project description
tcrsampler
Sample TCRs according to VDJ gene usage frequency
Install
pip install tcrsampler
Example
import os
import pandas as pd
from tcrsampler.sampler import TCRsampler
t = TCRsampler()
fn= os.path.join('tcrsampler' ,'tests', 'pmbc_mixcr_example_data.txt')
t.clean_mixcr(filename = fn)
t.build_background(stratify_by_subject = True, use_frequency = True)
t.sample([['TRBV9*01','TRBJ2-7*01', 2],['TRBV7-7*01', 'TRBJ2-4*01', 4] ], depth = 1, use_frequency = True)
[['CASSRTGSLADEQYF', 'CASSATGVVSAQYF'],
['CASSLGQAARGIQYF', 'CASSLGQAARGIQYF', 'CASSLGQAARGIQYF', 'CASSLGQAARGIQYF']]
Download Default Background
python -c "from tcrsampler.setup_db import install_all_next_gen; install_all_next_gen(dry_run = False)"
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