temp4hifu 0.1.2

A Python package designed to estimate the temperature increase due to high intensity focused ultrasound (HIFU) excitation

TEMP4HIFU

Author: Gerald Lee

Last Updated: 12/03/2024

Final Project, BIOEN 537: Computational System Biology. University of Washington, Seattle

A Python package designed to estimate the temperature increase due to high intensity focused ultrasound (HIFU) excitation.

BACKGROUND

High Intensity Focused Ultrasound (HIFU) and Focused Ultrasound (FUS) are used for thermal treatment of cells such as for cancer treatment. The generated increase of temperature during HIFU thermal treatment must be within safety guidelines for human use (44 degrees Celsius), which is essential for FDA approval and compliance. Accurate predictions of temperature bioeffects must be demonstrated through computational simulations before applications ex vivo and in vivo. Computational simulations requires modeling for both HIFU/FUS pressure fields and then the Bioheat equation; not complicated individually, but when combined can be tricky to navigate based on initial conditions.

Provided here is a tool to estimate bioheat from HIFU, usable as a GUI or importable as functions for integration with other code. The GUI provides an entry-friendly visualization of all aspects of bioheat due to HIFU.

INSTALLATION AND USE

This package is designed to be used within a provided GUI or as independent functions. Inputs

SETUP

pip install temp4hifu

PRE-REQUISITES

Ensure you have the following additional Python packages: 1. numpy 2. pandas 3. dash If not, please pip install these packages as well.

GUI

import temp4hifu.startApp temp4hifu.startApp

INDIVIDUAL FUNCTIONS

from temp4hifu import setParam, calculateBioheat, calculateRayleighIntegral setParam.setMedium(INPUT_ARG) calculateBioheat.generateVec(INPUT_ARG) calculateRayleighIntegral.generateField(INPUT_ARG)

GUI COMPONENTS AND FUNCTION NOTES

The GUI is able to perform and sustain the following actions: 1)

The function calculateRayleighIntegral.py allows the calculation of a pressure field in cylindrical coordinate space