tfce

Exact threshold-free cluster enhancement, and the permutation inference around it.

TFCE combines focal effects of large height with broad effects of large extent, and needs no cluster-forming threshold - the arbitrary choice that cluster-based inference forces on you, and that the result can depend on heavily.

pip install tfce

Wheels for Linux, macOS and Windows. No compiler needed.

Exact, not stepped

The TFCE of an element is an integral:

TFCE(v) = ∫ e_v(h)^E · h^H dh

over the extent e_v(h) of the cluster containing v at height h. Implementations normally approximate it by stepping h over a grid and summing. That costs a step size dh, a discretisation error that depends on it, and an accuracy parameter you have to guess.

This one doesn't. It builds the max-tree (the component tree) with union-find, and because e_v(h) is piecewise constant, integrates each piece in closed form. The answer is the integral, not a sample of it. There is nothing to tune.

The difference is not academic. Against a stepped implementation on a 60×72×60 volume:

steps	error vs exact
50	3.4%
100	1.7%
200	0.8%
400	0.4%

The error halves every time the steps double - first order, exactly as a step-size approximation must behave. The exact transform has no such term.

Quick start

import numpy as np
import tfce

# a volume: (nx, ny, nz)
t = tfce.tfce(stat_map, E=0.5, H=2.0)

# a surface: faces are 1-based, as GIFTI stores them
adj = tfce.adjacency_from_faces(faces, n_vertices)
t = tfce.tfce(surf_map, adjacency=adj, E=1.0, H=2.0)

# a block of permutations, one per thread
#   (nx, ny, nz, n_perm) -> (nx, ny, nz, n_perm)
t = tfce.tfce(perms, E=0.5, H=2.0, n_jobs=-1)

Volumes take connectivity=6 | 18 | 26 (26 is the default, and what fslmaths and the MATLAB toolbox use). Surfaces take the mesh, so the neighbourhood is whatever the mesh says it is.

Everything is arrays in, arrays out. No image objects, no file I/O, no design parsing - those belong in a layer above, so the core can be dropped anywhere.

Speed

Permutations are independent, so they are TFCE'd a block at a time, one per thread, with the GIL released. On the same 60×72×60 volume:

	one map	16 permutations
stepped (100 steps)	0.38 s	9.1 s - 569 ms/perm
tfce	0.03 s (14×)	0.13 s - 8 ms/perm (72×)

Using it with nilearn

nilearn has permuted_ols(..., tfce=True), and its TFCE is a stepped approximation. tfce ships a drop-in with the same signature:

from nilearn.mass_univariate import _utils
import tfce.nilearn_compat as tc

_utils.calculate_tfce = tc.calculate_tfce   # now exact, and much faster

It reads the neighbourhood out of the bin_struct it is handed, so it reproduces whichever connectivity the caller meant.

Fewer permutations

Counting exceedances cannot report a p-value below 1/n_perm. That floor - not the statistic - is what forces a permutation test to run many thousands of permutations, and it caps FDR too, since FDR is computed from the uncorrected p-values. tfce.tails removes it:

Gamma fit to the null of the maximum, for FWE-corrected p-values.
Generalised Pareto fit to each element's own tail, for the uncorrected ones - with the shape pooled across elements, since they all carry the same statistic under the same design and so differ in scale, not in shape.

From 1000 permutations this recovers p ≈ 1e-4 with the median right, where plain counting returns zero for 91% of elements and tells you nothing at all.

What's in the box


`tfce.core`	the exact transform - arrays in, arrays out
`tfce.tails`	Gamma and Generalised Pareto tail approximations
`tfce.glm`	the permuted GLM, which never forms the permuted data
`tfce.nilearn_compat`	drop-in for nilearn's `calculate_tfce`

Dependencies are deliberately thin: numpy and scipy, nothing else. nibabel is an optional extra, wanted only by I/O.

Trust

This is not a reimplementation. It is the same C core that the MATLAB TFCE toolbox has been running for years, with a Cython binding instead of a MEX one - so the two give bit-identical results, and the test suite holds them to it. It ships a validation suite of its own: the exactness of the max-tree is established against an independent stepped implementation, which must converge onto it at first order.

Citing

If you use this, please cite the method:

Smith SM, Nichols TE (2009). Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage 44:83–98. doi:10.1016/j.neuroimage.2008.03.061

The tail approximations are from:

Winkler AM, Ridgway GR, Douaud G, Nichols TE, Smith SM (2016). Faster permutation inference in brain imaging. NeuroImage 141:502–516. doi:10.1016/j.neuroimage.2016.05.068

Status

Early, but the parts that are here are tested and are the parts that matter. The transform, the tail approximations and the permuted GLM are done. Not yet done: the design layer - turning a BIDS Stats Model into a design matrix, contrasts and, crucially, an exchangeability structure. That last one is the real work, because BIDS-SM specifies X, Formula, Contrasts and GroupBy but has no concept of exchangeability blocks, so what may be permuted with what has to be defined on top of it rather than read out of it.

Documentation


Installation	Wheels, building from source, extras
Usage	Volumes, surfaces, batches, connectivity, `E` and `H`
A permutation test, end to end	The whole thing, as a worked example you can run
Theory	Why the integral is exact, and why you need fewer permutations
Using it with nilearn	The drop-in - and a bug in nilearn's stepped TFCE
API reference	Every public function
Benchmarks	Accuracy and speed, with scripts to reproduce
Validation	What the test suite establishes, and how

Links

Source, issues, MATLAB toolbox: https://github.com/ChristianGaser/tfce
Licence: BSD-3-Clause. Permissive on purpose: nilearn is BSD-3 and nipreps is Apache-2.0, and neither can take on a GPL dependency. Nothing here is derived from SPM, so nothing here has to be GPL. (The MATLAB/SPM toolbox in the same repository is GPL, because it genuinely is derived from SPM - see LICENSE.md.)

Developed by Christian Gaser, Structural Brain Mapping Group, Jena University Hospital.

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tfce 0.1.0

tfce

Exact, not stepped

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Using it with nilearn

Fewer permutations

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BLAKE2b-256	`debf2b3a780facc1b9e43007aeb92d2ec8592144a1bdf632e9f9377e336b4e00`

Algorithm	Hash digest
SHA256	`886e2a7b8f8a8d3f3b9a6a96a87f25a9a8782f109ee91b2aefcaa12833979d19`
MD5	`d8c5aa663d17218e3e1fbd43bd8b3de9`
BLAKE2b-256	`f0b7c822f40ab1d4512efda8c8df9bd007a2a13eae057d0a0a0c303cbbf3254a`

Algorithm	Hash digest
SHA256	`696ab9be14db79f6e71a457a4a4e9c20b9b2b06a3e36bea160ca50fa0e5a0797`
MD5	`185ab6002e142b529989a64ceed31a36`
BLAKE2b-256	`c3da4d754b015633c1c61aae222a4e8aadcbecb4bab3226ffe96340066db8567`

Algorithm	Hash digest
SHA256	`a50898b5c0d5c89fe33c891268c528c0fb24bdbb461844164cbb61e947d62727`
MD5	`c3eb416887f557cdf350d1984ca93d1d`
BLAKE2b-256	`4ed70c70ec41b4f7cfa1be192463f1259483ed92a134c13fdeea9e94ba4c1f11`

Algorithm	Hash digest
SHA256	`4858a86630365ee58f85126dbde4965cd313cfa8422beb7a52c9f1c3cd844502`
MD5	`4c0ad036d1e98dec93e390a05cb57441`
BLAKE2b-256	`483a63f1433ca8a3265d3a0f509add4405f2da58d3ebfad7a43cb68b8e56fe52`

Algorithm	Hash digest
SHA256	`20bf91bdf2dd4cf843ff220829fb409769bbe145f7b9ae424e1b06912a2cd531`
MD5	`a5304a122ae4d8329b5d09520676f6c6`
BLAKE2b-256	`f709bd91521b6b4247d69f333ef547d2bfc84d19eda6b8ca1175ac6bcb601652`

Algorithm	Hash digest
SHA256	`bf4cf1370479ceff29a7c035733f8166560b36dd1b27b529d22627d433caa3ef`
MD5	`dcb5bebf606cd3f84f0c447217f610af`
BLAKE2b-256	`e89683732a26b2dfb4c83e7ba05de7f66179e721862113c34802040e2e53566c`