viprs: Variational Inference of Polygenic Risk Scores
viprs is a python package that implements variational inference techniques to estimate the posterior distribution
of variant effect sizes conditional on the GWAS summary statistics. The package is designed to be fast and accurate,
and to provide a variety of options for the user to customize the inference process.
Highlighted features:
- The coordinate ascent algorithms are written in
C/C++andcythonfor improved speed and efficiency. - The code is written in object-oriented form, allowing the user to extend and experiment with existing implementations.
- Different priors on the effect size: Spike-and-slab, Sparse mixture, etc.
- We also provide scripts for different hyperparameter tuning strategies, including: Grid search, Bayesian optimization, Bayesian model averaging.
- Easy and straightforward interfaces for computing PRS from fitted models.
- Implementation for a wide variety of evaluation metrics for both binary and continuous phenotypes.
Helpful links
AI Usage
This project is developed using AI-assisted technologies. Please review our AI Declaration for full transparency on automated pipelines.
1 maintainer
Metadata
1 maintainer
Release files for viprs 0.1.5
For a detailed explanation of source distributions (sdists) and built distributions (wheels), please see the package formats documentation.
Source distribution (sdist)
| File | Size | Uploaded | |
|---|---|---|---|
| viprs-0.1.5.tar.gz | 91.8 kB | Details |
Built distributions (wheels)
| File | Reset | |||
|---|---|---|---|---|
| viprs-0.1.5-cp313-cp313-win_amd64.whl | CPython 3.13 | CPython 3.13 | Windows x86-64 | Details |
| viprs-0.1.5-cp313-cp313-manylinux_2_27_x86_64.manylinux_2_28_x86_64.whl | CPython 3.13 | CPython 3.13 | Linux glibc 2.28+ x86-64, Linux glibc 2.27+ x86-64 | Details |
| viprs-0.1.5-cp313-cp313-macosx_11_0_arm64.whl | CPython 3.13 | CPython 3.13 | macOS 11.0+ ARM64 | Details |
| viprs-0.1.5-cp313-cp313-macosx_10_13_x86_64.whl | CPython 3.13 | CPython 3.13 | macOS 10.13+ x86-64 | Details |
| viprs-0.1.5-cp312-cp312-win_amd64.whl | CPython 3.12 | CPython 3.12 | Windows x86-64 | Details |
| viprs-0.1.5-cp312-cp312-manylinux_2_27_x86_64.manylinux_2_28_x86_64.whl | CPython 3.12 | CPython 3.12 | Linux glibc 2.27+ x86-64, Linux glibc 2.28+ x86-64 | Details |
| viprs-0.1.5-cp312-cp312-macosx_11_0_arm64.whl | CPython 3.12 | CPython 3.12 | macOS 11.0+ ARM64 | Details |
| viprs-0.1.5-cp312-cp312-macosx_10_13_x86_64.whl | CPython 3.12 | CPython 3.12 | macOS 10.13+ x86-64 | Details |
| viprs-0.1.5-cp311-cp311-win_amd64.whl | CPython 3.11 | CPython 3.11 | Windows x86-64 | Details |
| viprs-0.1.5-cp311-cp311-manylinux_2_27_x86_64.manylinux_2_28_x86_64.whl | CPython 3.11 | CPython 3.11 | Linux glibc 2.28+ x86-64, Linux glibc 2.27+ x86-64 | Details |
| viprs-0.1.5-cp311-cp311-macosx_11_0_arm64.whl | CPython 3.11 | CPython 3.11 | macOS 11.0+ ARM64 | Details |
| viprs-0.1.5-cp311-cp311-macosx_10_9_x86_64.whl | CPython 3.11 | CPython 3.11 | macOS 10.9+ x86-64 | Details |
| viprs-0.1.5-cp310-cp310-win_amd64.whl | CPython 3.10 | CPython 3.10 | Windows x86-64 | Details |
| viprs-0.1.5-cp310-cp310-manylinux_2_27_x86_64.manylinux_2_28_x86_64.whl | CPython 3.10 | CPython 3.10 | Linux glibc 2.28+ x86-64, Linux glibc 2.27+ x86-64 | Details |
| viprs-0.1.5-cp310-cp310-macosx_11_0_arm64.whl | CPython 3.10 | CPython 3.10 | macOS 11.0+ ARM64 | Details |
| viprs-0.1.5-cp310-cp310-macosx_10_9_x86_64.whl | CPython 3.10 | CPython 3.10 | macOS 10.9+ x86-64 | Details |
Total release size: 15.4 MB
Release files / viprs-0.1.5.tar.gz
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Release files / viprs-0.1.5-cp313-cp313-win_amd64.whl
| Download URL | viprs-0.1.5-cp313-cp313-win_amd64.whl |
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Release files / viprs-0.1.5-cp313-cp313-manylinux_2_27_x86_64.manylinux_2_28_x86_64.whl
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Release files / viprs-0.1.5-cp313-cp313-macosx_11_0_arm64.whl
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Release files / viprs-0.1.5-cp312-cp312-win_amd64.whl
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Release files / viprs-0.1.5-cp311-cp311-win_amd64.whl
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