watney 4.0.1

Interactive NiceGUI oncology annotation platform for reviewing LLM-extracted progression events and systemic therapy timelines.

WATNEY

WATNEY is an interactive NiceGUI-based oncology annotation platform for reviewing and validating LLM-extracted progression events and systemic therapy timelines from longitudinal clinical notes.

Developed by Justin Vinh at Dana-Farber Cancer Institute.

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Features

• Review LLM-extracted progression events
• Assign progression events to systemic therapy agents
• Add clinician-derived progression events manually
• View longitudinal oncology notes with evidence highlighting
• Track reviewer annotations in SQLite
• Export annotations to CSV
• Multi-user annotation support
• Persistent configuration and session settings
• Interactive patient navigation interface

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Installation

Install from PyPI

pip install watney

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Launching WATNEY

After installation:

watney

This launches the NiceGUI application locally in your browser.

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Required Input Data

WATNEY expects a CSV containing:

• Longitudinal note text
• LLM extraction JSON
• Patient identifiers

The following columns are required:

Column Name	Description
DFCI_MRN	Patient identifier
all_notes	Concatenated longitudinal notes
generation	LLM-generated JSON extraction

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Expected Note Formatting

Notes should contain metadata fields similar to:

Note Number: 1
Note Report ID: REPORT123
Note Date: 2024-01-01
Note Dept: Medical Oncology
Note Author: Jane Smith

Notes should be separated using:

====================

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Expected JSON Structure

The generation column should contain JSON with structures similar to:

{
  "systemic_therapy": {
    "agents": [
      {
        "drug_name": "Pembrolizumab",
        "intervals": [
          {
            "start_date": "2023-01-01",
            "end_date": "2023-06-01"
          }
        ]
      }
    ]
  },
  "progression": {
    "progression_events": [
      {
        "progression_date": "2023-07-01",
        "confidence_level": "high",
        "progression_date_rationale": {
          "report_id": "REPORT123",
          "note_date": "2023-07-01",
          "author": "Dr. Smith",
          "text": "Evidence excerpt here"
        }
      }
    ]
  }
}

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First-Time Setup

When WATNEY launches:

1. Enter your username
2. Provide the path to your extraction CSV
3. WATNEY will persist this configuration locally
4. Future launches automatically reload the prior CSV

Configuration is stored in:

./watney_annotations/watney_config.json

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Annotation Database

Annotations are automatically stored in SQLite.

Default database location:

./watney_annotations/progression_annotations_database.db

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User Workflow

1. Review LLM Progression Events

The left panel displays:

• Extracted progression dates
• Confidence levels
• Supporting evidence
• Source metadata

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2. Navigate to Source Notes

Click:

Source

WATNEY automatically:

• Navigates to the originating note
• Scrolls to the evidence
• Highlights the relevant text

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3. Assign Progression Events to Agents

For each progression event:

1. Select a systemic therapy agent
2. Click:

Save Agent Assignment

Assignments are immediately persisted to SQLite.

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4. Add Clinician-Derived Events

Use:

Add Clinician Progression Event

Fields include:

• Progression date
• Agent
• Evidence
• Report ID
• Determined by

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5. Export Annotations

Click:

Export

WATNEY exports all annotations as a timestamped CSV.

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Navigation Controls

Button	Function
Prev	Previous patient
Next	Next patient
Patient List	Open patient navigator
Export	Export annotations
Settings	Configure paths and database

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License

MIT License

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Citation

Justin Vinh. WATNEY: Interactive Oncology Annotation Platform.
https://github.com/justin-vinh/watney