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Project description
DILImap is a pioneering toxicogenomics atlas purpose-built for modeling Drug-Induced Liver Injury (DILI). It features RNA-seq profiles from primary human hepatocytes exposed to 300 diverse compounds. It offers a powerful foundation for mechanistic insight and predictive modeling.
ToxPredictor, trained on DILImap, sets a new benchmark in DILI risk assessment. With 89% sensitivity at 100% specificity, it outperforms traditional methods and reliably flags even the most elusive DILI-prone drugs, including withdrawn and idiosyncratic compounds.
Usage & Support
Installation: Install using
pip install dilimapDocumentation & Notebooks: Visit dilimap.org for detailed usage instructions and reproducibility notebooks. (Note: Access is restricted — see manuscript for the tokenized link.)
Support: Reach out at DILImap@cellarity.com with any questions or feedback.
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