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FiTree

FiTree is a Python package for Bayesian inference of fitness landscapes via tree-structured branching processes.

Installation

pip install fitree

Getting started

FiTree takes tumor mutation trees as input and learns a matrix representing the fitness effects of individual mutations as well as their pairwise interactions. We provide small examples on how to use FiTree:

  1. Pre-processing of tree input

  2. Tree generation and inference

For large-scale simulation studies and real data application, we recommend looking into the snakemake workflows.

Preprint

The preprint of the paper is provided here.

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