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Analyze antibody repertoires and discover new V genes

Project description


IgDiscover analyzes antibody repertoires and discovers new V genes from high-throughput sequencing reads. Heavy chains, kappa and lambda light chains are supported (to discover VH, VK and VL genes).

IgDiscover is the result of a collaboration between the Gunilla Karlsson Hedestam group at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet, Sweden and the Bioinformatics Long-Term Support facility at Science for Life Laboratory (SciLifeLab), Sweden.

If you use IgDiscover, please cite:

Corcoran, Martin M. and Phad, Ganesh E. and Bernat, Néstor Vázquez and Stahl-Hennig, Christiane and Sumida, Noriyuki and Persson, Mats A.A. and Martin, Marcel and Karlsson Hedestam, Gunilla B.
Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.
Nature Communications 7:13642 (2016)

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