anasim-simulator 1.0

Real-time anesthesia and physiology simulator for medical education

AnaSim

Real-time anesthesia and physiology simulation for medical education.

[!WARNING] For educational use only

AnaSim is not a medical device. Do not use it for clinical care or patient-specific prediction.

Installation

AnaSim requires Python 3.10 or newer. Install the published package in a virtual environment:

python3 -m venv .venv
source .venv/bin/activate
python -m pip install anasim-simulator

On Windows, activate the environment with .venv\Scripts\activate.

The package is distributed as anasim-simulator; the command and Python import are anasim.

Quick start

Launch the interactive operating-room monitor:

anasim

Run a headless simulation:

anasim --mode headless --duration 10

See the CLI guide for configuration files, recording, and additional examples.

Features

• Cardiovascular and respiratory physiology responding to drugs, ventilation, fluids, and surgical stimulation
• PK/PD models for propofol, remifentanil, sevoflurane, rocuronium, and vasoactive agents
• VCV, PCV, PSV, CPAP, and manual bag-mask ventilation
• ECG, pulse oximetry, capnography, NIBP, and depth-of-anesthesia monitoring
• Guided induction, hemorrhage, anaphylaxis, septic shock, and emergence scenarios
• Headless execution and CSV recording for reproducible teaching exercises

Model scope and calibration

AnaSim uses published models where they behave coherently in the integrated simulation and documents calibrated deviations where literal parameters produce implausible managed intraoperative states. See the model references and deviations for citations and details.

Examples of calibration choices and deliberate deviations:

• hemodynamics uses plasma propofol/remifentanil concentrations in line with Su et al. 2023, while CNS depth, tolerance, BIS, and respiratory depression use effect-site concentrations
• rocuronium spontaneous recovery uses a faster runtime ke0 than pure literature modeling so recovery timing stays in the clinical range
• maintenance startup adds visible norepinephrine support only when the selected anesthetic state would otherwise begin below MAP 65 mmHg

AnaSim currently accepts adult patients aged 18–70 years. The upper bound avoids unsupported extrapolation of the strongly age-dependent Su et al. hemodynamic term beyond the population used to develop and illustrate that model.

Development

git clone https://github.com/robchiral/AnaSim.git
cd AnaSim
python3 -m venv .venv
source .venv/bin/activate
python -m pip install -e ".[dev]"
QT_QPA_PLATFORM=offscreen python -m pytest -q

See the contribution guide and changelog.

Initial TIVA implementations were derived from Python Anesthesia Simulator.

License

AnaSim is released under the MIT License.