AnaSim

AnaSim is an adult anesthesia simulator for teaching and research. It runs published drug and cardiorespiratory models in real time, with a patient monitor and anesthesia machine interface.

Run AnaSim

Open robche.com/AnaSim in your browser.

To run locally, install with Python 3.10 or later.

python3 -m venv .venv
source .venv/bin/activate      # Windows: .venv\Scripts\activate
python -m pip install anasim-simulator
anasim

anasim opens a local browser session and works offline. Stop the server with Ctrl+C.

Use a session

For a first session, choose Guided scenario and TIVA induction. For open practice, choose Open simulation and either Awake before induction or Anesthetized maintenance. Choose Start simulation, then Start below the monitor.

Manual infusion rates are the default. Select Allow TCI during setup to use target controls and TCI maintenance starts. Scenario instructions follow this setting. Propofol and remifentanil rates use mcg/kg/min.

Use Apply or Enter to save settings and Escape to cancel edits. For mechanical ventilation, select a facemask or tracheal tube, apply a mode, and choose Start ventilator.

Local CSV recordings go to recordings/ where you launched anasim; hosted recordings download when stopped.

Features

• Drugs include propofol, remifentanil, fentanyl, midazolam, etomidate, ketamine, lidocaine, sevoflurane, rocuronium, sugammadex, norepinephrine, epinephrine, phenylephrine, vasopressin, dobutamine, milrinone, esmolol, labetalol, and glycopyrrolate. Delivery includes bolus, infusion, and effect-site target-controlled infusion (TCI) where supported.
• Machine options include a facemask or tracheal tube, fresh gas flow, a vaporizer, bag-mask ventilation, and VCV, PCV, PCV-VG, SIMV, PSV, or CPAP.
• The monitor shows ECG, SpO₂, arterial pressure, NIBP, capnography, ventilation waveforms and loops, gas values, BIS, TOF, temperature, fluid balance, and alarms.
• Events include fluids and blood, surgical stimulation, airway obstruction, bronchospasm, laryngospasm, hemorrhage, anaphylaxis, sepsis, and arrhythmias.
• Guided scenarios cover TIVA and inhalational induction and emergence, hemorrhage, anaphylaxis, septic shock, and oxygen supply failure.

Limits

AnaSim supports adults aged 18 to 70 years, with input limits. Architecture describes source populations and teaching calibrations. Acid-base balance, lactate, tissue oxygen debt, machine pneumatics, and CPR are not modeled.

Headless use

anasim --mode headless --duration 60 --record

Documentation

Citation and license

Cite using CITATION.cff. Licensed under MIT. The first TIVA implementation was derived from Python Anesthesia Simulator.