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AnaSim

AnaSim simulates adult anesthesia for education and research. It combines published pharmacology and cardiorespiratory models with a patient monitor and anesthesia machine interface.

CI PyPI Python 3.10+ License: Noncommercial

Run AnaSim in your browser

AnaSim patient monitor and controls during guided induction

Run AnaSim

Open robche.com/AnaSim in your browser.

For local use, install with Python 3.10 or later.

python3 -m venv .venv
source .venv/bin/activate
python -m pip install anasim-simulator
anasim

In Windows Command Prompt, use python in place of python3 and activate with .venv\Scripts\activate.bat. anasim opens the interface in your browser and works offline after installation. Press Ctrl+C in the terminal to stop the server.

Choose a guided scenario or open simulation, then select Start simulation and Start. Use Apply to confirm setting changes.

Features

Feature Supported controls and measurements
Anesthesia Propofol, remifentanil, fentanyl, midazolam, etomidate, ketamine, lidocaine, sevoflurane, nitrous oxide, rocuronium, and sugammadex
Cardiovascular drugs Norepinephrine, epinephrine, phenylephrine, vasopressin, dobutamine, milrinone, esmolol, labetalol, and glycopyrrolate
Anesthesia machine Facemask or tracheal tube, fresh gas flow, vaporizer, and bag-mask ventilation
Ventilation Volume control (VCV), pressure control (PCV), pressure control with volume guarantee (PCV-VG), synchronized intermittent mandatory ventilation (SIMV), pressure support (PSV), and continuous positive airway pressure (CPAP)
Monitoring ECG, pulse oximetry, arterial and noninvasive blood pressure, capnography, ventilation waveforms and loops, gas concentrations, bispectral index (BIS), train-of-four (TOF), temperature, fluid balance, trends, and alarms
Fluids and events Fluids and blood, surgical stimulation, airway obstruction, bronchospasm, laryngospasm, hemorrhage, anaphylaxis, sepsis, and arrhythmias
Guided scenarios Total intravenous anesthesia (TIVA) and balanced induction, TIVA and inhalational emergence, hemorrhage, anaphylaxis, septic shock, and oxygen supply failure

Drug delivery supports boluses, manual infusions, and plasma or effect-site TCI, depending on the drug.

Limits

AnaSim supports adults aged 18 to 70 years within the input limits. The architecture guide describes source populations, simulator calibrations, and model limits. Acid-base balance, lactate, tissue oxygen debt, machine pneumatics, and cardiopulmonary resuscitation are not modeled.

Headless use

Run a 60-second simulation and save a CSV recording.

anasim --mode headless --duration 60 --record

Documentation

Task Guide
Configure patients, run scripts, or interpret CSV CLI and Python usage
Understand model behavior and assumptions Architecture
Find the source studies Model references
Compare model outputs with clinical recordings VitalDB validation
Change the code and choose checks Contributing
Review release changes Changelog

Citation and license

Cite using CITATION.cff.

AnaSim 1.6 and later use the proprietary, source-available AnaSim noncommercial license.

Use Terms
Individual study, experimentation, and code changes Free, including for students, residents, and clinicians
Noncommercial teaching, assessment, research, and internal deployment at nonprofit or government institutions Free, including internal hosting for participants
Commercial use, other institutional use, or hosting outside that exemption Paid license

Contact Robert Chen for paid licenses or written fee waivers. Sharing copies is allowed under the license terms. Earlier releases retain their MIT terms.

Early AnaSim versions adapted code from Python Anesthesia Simulator, licensed under GPL-3.0. Those implementations have since been substantially rewritten. Third-party material retains its own terms.

Metadata

Release files for anasim-simulator 1.6

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