bio2bel-wikipathways 0.1.0.dev0

A package for converting Wikipathways to BEL

This package allows the enrichment of BEL networks with WikiPathways information by wrapping its RESTful API. Furthermore, it is integrated in the ComPath environment for pathway database comparison.

Installation

bio2bel_wikipathways can be installed easily from PyPI with the following code in your favorite terminal:

$ python3 -m pip install bio2bel_wikipathways

or from the latest code on GitHub with:

$ python3 -m pip install git+https://github.com/bio2bel/wikipathways.git@master

Setup

WikiPathways can be downloaded and populated from either the Python REPL or the automatically installed command line utility.

The following resources will be automatically installed and loaded in order to fully populate the tables of the database:

• Bio2BEL HGNC

Python REPL

>>> import bio2bel_wikipathways
>>> wikipathways_manager = bio2bel_wikipathways.Manager()
>>> wikipathways_manager.populate()

Command Line Utility

bio2bel_wikipathways populate

Other Command Line Utilities

• Run an admin site for simple querying and exploration python3 -m bio2bel_wikipathways web (http://localhost:5000/admin/)

• Export gene sets for programmatic use python3 -m bio2bel_wikipathways export

Citation

• Slenter, D.N., et al WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research Nucleic Acids Research, (2017) doi.org/10.1093/nar/gkx1064

• Kutmon, M., et al. WikiPathways: capturing the full diversity of pathway knowledge Nucl. Acids Res., 44, D488-D494 (2016) doi:10.1093/nar/gkv1024

• Kelder, T., et al. WikiPathways: building research communities on biological pathways. Nucleic Acids Res. 2012 Jan;40(Database issue):D1301-7