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Simulate and render the flux of Ribosomes through Ribosomal Phase Space

Project description

DYNORDG

Dynamic Ribosome Decision Graphs (RDGs) for simulating and visualizing ribosome flux along transcripts.

Overview

A Ribosome Decision Graph (RDG) models the possible paths a ribosome can take along an mRNA transcript.

Dynamic RDGs extend this by:

  • Representing ribosome flux using edge thickness
  • Implicitly encoding overlapping translons via flow rather than explicit separation
  • Modeling ribosomal phase states based on downstream potential

This package provides tools to:

  • Build RDGs from transcript sequences, or from user defined phase transistions
  • Simulate ribosome movement
  • Render dynamic flux graphs

Installation

pip install dynordg

Quick Start

from dynordg import Transcript, RiboGraphFlux, RiboGraphVis

# Create transcript
t = Transcript("AUGGCCAUGGCGCCCAGAACUGGGUAA")

# Automatically detect start/stop events
t.auto_stop_starts()

# Build flux graph
graph = RiboGraphFlux(t.transition_map())

# Create render object
plot = RiboGraphVis(graph)

# Render
plot.show()

Example Output

Below is example dynamic RDG (if not a realistic one):

Example RDG

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