Infer tree sequences from genetic variation data.

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  • License: GNU General Public License v3 or later (GPLv3+) (GNU GPLv3+)
  • Author: Tskit Developers
  • Tags population genetics , tree sequence , ancestral recombination graph , evolutionary tree , inference , tsinfer
  • Requires: Python >=3.7
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tsinfer

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Infer a tree sequence from genetic variation data

The documentation contains details of how to use this software, including installation instructions.

The algorithm, its rationale, and results from testing on simulated and real data are described in the following Nature Genetics paper:

Jerome Kelleher, Yan Wong, Anthony W Wohns, Chaimaa Fadil, Patrick K Albers and Gil McVean (2019) Inferring whole-genome histories in large population datasets. Nature Genetics 51: 1330-1338

Please cite this if you use tsinfer in your work. Code to reproduce the results in the paper is present in a separate GitHub repository.

Note that tsinfer does not attempt to infer node times (i.e. branch lengths of the inferred trees). If you require a tree sequence where the dates of common ancestors are expressed in calendar or generation times, you should post-process the tsinfer output using software such as tsdate.

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  • License: GNU General Public License v3 or later (GPLv3+) (GNU GPLv3+)
  • Author: Tskit Developers
  • Tags population genetics , tree sequence , ancestral recombination graph , evolutionary tree , inference , tsinfer
  • Requires: Python >=3.7
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0.5.1

0.5.0

0.4.2 yanked

Reason this release was yanked:

Changelog missed material changes to the algorithm

0.4.1

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0.4.0a1 pre-release

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0.3.2

This version

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0.3.0

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0.2.1

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0.1.4

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