PyEnsembl
PyEnsembl queries Ensembl genes, transcripts, exons and sequences from local indexes. It supports numbered releases, dated new-platform annotations and custom matched GTF/FASTA files.
Installation
Use Python 3.11 or later. Install the package and one explicit annotation:
python -m pip install pyensembl
pyensembl install --release 93 --species human
This selects human GRCh38 and downloads and indexes its annotation, transcript and peptide files. Setup takes several minutes and disk space; whole-genome DNA is optional. See installation and first lookup.
Example Usage
After installing the data above:
from pyensembl import EnsemblRelease
with EnsemblRelease(93, species="human") as data:
gene = data.gene_by_id("ENSG00000141510")
print(gene.name, gene.contig, gene.start, gene.end, gene.strand)
TP53 17 7661779 7687550 -
Coordinates are one-based and inclusive; TP53 is on the minus strand. Pin the release you analyze: coordinates, IDs and sequences can change between releases, and a gene name can match several loci. The documentation continues with protein and transcript sequences.
Documentation
The documentation home page includes installation and getting-started examples. Use these guides for other tasks:
| Task | Guide |
|---|---|
| Find genes by name, position or biotype | Genes and transcripts |
| Protein, coding and transcript sequences; exons | Get protein and transcript sequences |
| Search additional gene names | Alias lookup |
| Read genomic DNA | Reference DNA |
| Choose an assembly, species and coverage | Assembly selection |
| Install from Python, check or delete data | Install and manage data |
| Use your own annotations | Custom genomes |
| Use dated Ensembl downloads | Dated annotations |
| Find a class or query method | API reference |
For contributions, see development setup,
documentation style and
releasing. Every PR includes a version bump, lint and
tests; maintainers merge through a PR and publish with ./deploy.sh from clean main.
5 maintainers
Metadata
5 maintainers
Release files for pyensembl 2.32.3
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Source distribution (sdist)
| File | Size | Uploaded | Provenance | Actions |
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| pyensembl-2.32.3.tar.gz | 513.4 kB | Without provenance | Details for pyensembl-2.32.3.tar.gz |
Built distribution (wheel)
| File | Interpreter | ABI | Platform | Actions Reset |
|---|---|---|---|---|
| pyensembl-2.32.3-py3-none-any.whl | Python 3 | none | any | Details for pyensembl-2.32.3-py3-none-any.whl |
Total release size: 680.4 kB
Release files / pyensembl-2.32.3.tar.gz
| Download URL | pyensembl-2.32.3.tar.gz |
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| Download URL | pyensembl-2.32.3-py3-none-any.whl |
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